Reduction in tumor grade and Ki-67 in postmenopausal patient with node-positive invasive ductal carcinoma following combination hormone replacement therapy cessation: a case report

Background: While praised for its benefits in treating symptoms related to menopausal changes, hormone replacement therapy (HRT) has been associated with an increased risk hormone-dependent cancer development, particularly endometrial and breast. Few studies have elucidated the relationship between HRT cessation receptor-positive breast proliferation. We report herein, best of our knowledge, first case 28.6% relative reduction proliferation index marker Ki-67 node-positive following cessation.